ADDISON METABOLIC

Peptide Education

Science-backed research on every compound in the Addison Metabolic protocol library.

Research Use Only: This information is for educational and research purposes only. All information is based on publicly available clinical trial data and peer-reviewed literature. Products are not FDA-approved and are not intended for human use. Always consult a licensed healthcare provider before making any medical decisions.
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Medical & Research Disclaimer

Please read carefully before reviewing any compound information on this page.

For Educational Purposes Only — Not Medical Advice

All content on this page, including compound descriptions, research summaries, key benefits, and research notes, is provided for informational and educational purposes only. Nothing on this page constitutes medical advice, diagnosis, or treatment. This content should not be used as a substitute for professional medical advice from a licensed physician or qualified healthcare provider. Never disregard professional medical advice or delay seeking it because of something you have read here.

FDA Regulatory Status

Many of the compounds described on this page have not been evaluated or approved by the U.S. Food and Drug Administration (FDA) for safety or efficacy in humans. Where FDA approval is noted (e.g., Tirzepatide, Tesamorelin, Sermorelin), such approval applies only to the specific indications stated in the relevant prescribing information. References to clinical trials and research publications do not imply that any compound is approved for general use or available without a valid prescription from a licensed provider.

Compounded Peptides & Prescription Requirements

Peptide therapies offered through Addison Metabolic are compounded medications prescribed by licensed healthcare providers and dispensed by licensed compounding pharmacies. Compounded medications are not FDA-approved drug products. They are prepared for individual patients pursuant to a valid prescription and are not commercially manufactured. All peptide protocols at Addison Metabolic require a consultation with a licensed provider, a valid prescription, and ongoing medical supervision.

Third-Party Research References

References to scientific studies, clinical trials, and peer-reviewed literature are provided for informational purposes only. Many studies referenced involve animal models or in vitro conditions that may not translate directly to human outcomes. Such references do not imply that any compound has been proven safe or effective for any specific human use. Addison Metabolic does not endorse or guarantee the accuracy of any third-party research cited on this page.

Individual Results May Vary

Results described in research literature or referenced in compound summaries are not guaranteed and may not reflect outcomes for any individual patient. Peptide therapy outcomes depend on many factors including individual health status, genetics, lifestyle, adherence to protocol, and provider supervision. Always consult your Addison Metabolic provider to determine whether any protocol is appropriate for your specific health goals and medical history.

No Physician-Patient Relationship

Reviewing the educational content on this page does not create a physician-patient relationship or any other professional healthcare relationship with Addison Metabolic or its providers. A formal consultation, medical history review, and valid prescription are required before any peptide therapy may be initiated.

Questions? Contact Addison Metabolic at 214-899-2726 or book a consultation with a licensed provider.

THE BASICS

What Peptides Should I Learn About?

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What is a peptide — infographic explaining peptide science
Metabolic

Metabolic Protocols

Fat metabolism, cellular energy, weight management, mitochondrial & GLP-1 support

Small Molecule Inhibitor

5-AMINO-1MQ

A selective inhibitor of NNMT (nicotinamide N-methyltransferase), an enzyme overexpressed in fat tissue. By blocking NNMT, 5-Amino-1MQ raises NAD+ levels and activates metabolic pathways that promote fat burning.

Key Benefits

  • Promotes fat cell reduction
  • Raises intracellular NAD+ levels
  • Supports healthy weight management
  • May improve insulin sensitivity
Research NotePreclinical studies show significant reductions in fat mass and improvements in metabolic markers without changes to diet or exercise.
Starting at$100 / 5mg vial
GH Fragment Peptide

AOD-9604

A modified fragment of human growth hormone (hGH) that mimics the way natural hGH regulates fat metabolism. Unlike full hGH, AOD-9604 does not affect blood sugar or IGF-1 levels.

Key Benefits

  • Stimulates lipolysis (fat breakdown)
  • Inhibits lipogenesis (fat storage)
  • No effect on blood glucose or IGF-1
  • Supports lean body composition
Research NoteOriginally developed by Monash University, AOD-9604 has been studied in multiple human clinical trials for obesity management with a strong safety profile.
Starting at$90 / 5mg vial
Amylin Analogue

Cagrilintide

A long-acting amylin analogue that works on the brain's appetite-regulating centers to reduce hunger and slow gastric emptying. Often combined with GLP-1 agonists for synergistic weight loss.

Key Benefits

  • Reduces appetite and caloric intake
  • Slows gastric emptying
  • Supports sustained weight loss
  • Synergistic with GLP-1 therapies
Research NotePhase 2 trials combining cagrilintide with semaglutide showed up to 17% body weight reduction over 32 weeks.
Starting at$220 / 10mg vial
Mitochondrial-Derived Peptide

MOTS-C

Encoded within mitochondrial DNA, MOTS-C regulates metabolic homeostasis and activates AMPK — the body's master energy sensor. It improves insulin sensitivity and promotes fat utilization.

Key Benefits

  • Activates AMPK energy pathways
  • Improves insulin sensitivity
  • Enhances fat oxidation
  • Supports mitochondrial function
Research NoteResearch published in Cell Metabolism demonstrated MOTS-C's role in regulating metabolic flexibility and its potential as an exercise mimetic.
Starting at$290 / 40mg vial
GLP-3 Receptor Agonist

RETA-GLP3

An advanced GLP-3 receptor agonist that supports glucose regulation and metabolic balance through gut-derived signaling pathways distinct from GLP-1.

Key Benefits

  • Supports glucose homeostasis
  • Complements GLP-1 therapy
  • Gut-derived metabolic signaling
  • Supports healthy body composition
Research NoteEmerging research highlights GLP-3 pathways as a complementary target to GLP-1 for comprehensive metabolic management.
Starting at$155 / 10mg vial
ERR Agonist

SLU-PP-332

A potent agonist of estrogen-related receptors (ERRα/γ) that mimics the metabolic effects of endurance exercise at the cellular level — often called an 'exercise in a molecule.'

Key Benefits

  • Mimics endurance exercise effects
  • Enhances mitochondrial biogenesis
  • Promotes fat oxidation
  • Improves cardiovascular endurance markers
Research NotePublished in the Journal of Medicinal Chemistry, SLU-PP-332 demonstrated significant improvements in exercise capacity and fat metabolism in preclinical models.
Starting at$245 / 5mg vial
Dual GIP/GLP-1 Receptor Agonist

Tirzepatide

A once-weekly dual agonist targeting both GIP and GLP-1 receptors, producing superior weight loss and glycemic control compared to GLP-1 agonists alone.

Key Benefits

  • Up to 22% body weight reduction in trials
  • Improves HbA1c and blood glucose
  • Reduces appetite and food intake
  • Dual receptor mechanism for enhanced efficacy
Research NoteThe SURMOUNT clinical trial program demonstrated Tirzepatide's best-in-class efficacy for weight management, with FDA approval for type 2 diabetes (Mounjaro) and obesity (Zepbound).
Starting atMembership pricing starts at $129
Recovery

Recovery Protocols

Tissue repair, joint regeneration, anti-inflammatory & connective tissue support

Body Protection Compound

BPC-157

A 15-amino acid peptide derived from a protein found in gastric juice. BPC-157 is one of the most studied regenerative peptides, with remarkable healing effects on tendons, ligaments, muscles, and the GI tract.

Key Benefits

  • Accelerates tendon and ligament healing
  • Reduces inflammation
  • Supports GI tract repair
  • Promotes angiogenesis (new blood vessel formation)
Research NoteExtensive preclinical research shows BPC-157 heals damaged tissues faster than controls across multiple injury models, with an excellent safety profile.
Starting at$140 / 10mg vial
Tripeptide

CARTALAX

A short tripeptide (Ala-Glu-Asp-Gly) that supports cartilage and connective tissue health by regulating gene expression related to extracellular matrix production.

Key Benefits

  • Supports cartilage regeneration
  • Promotes collagen synthesis
  • Reduces joint degradation markers
  • Anti-aging effects on connective tissue
Research NoteResearch from the St. Petersburg Institute of Bioregulation shows CARTALAX's role in slowing age-related connective tissue decline.
Starting at$200 / 20mg vial
Alpha-MSH Fragment

KPV

A tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH) with potent anti-inflammatory properties. KPV acts directly on immune cells to reduce inflammatory cytokine production.

Key Benefits

  • Potent anti-inflammatory action
  • Supports gut barrier integrity
  • May help with inflammatory bowel conditions
  • Immune-modulating properties
Research NoteStudies demonstrate KPV's ability to reduce intestinal inflammation and support mucosal healing, making it a focus for GI inflammatory conditions.
Starting at$90 / 10mg vial
Thymosin Beta-4 Fragment

TB-500

A synthetic version of Thymosin Beta-4, a naturally occurring peptide present in virtually all human cells. TB-500 promotes cell migration, reduces inflammation, and accelerates healing of muscles, tendons, and skin.

Key Benefits

  • Promotes muscle and tendon repair
  • Reduces acute and chronic inflammation
  • Supports flexible connective tissue
  • Promotes hair growth in some studies
Research NoteTB-500 has been studied extensively in athletic recovery contexts, with research showing accelerated healing timelines and reduced scar tissue formation.
Starting at$230 / 10mg vial
Performance

Performance Protocols

Growth hormone optimization, lean muscle, endurance & recovery support

GHRH Analogue

CJC-1295 DAC

A long-acting growth hormone releasing hormone (GHRH) analogue with a Drug Affinity Complex (DAC) that extends its half-life to 6–8 days. Produces sustained elevation of GH and IGF-1 levels.

Key Benefits

  • Sustained GH and IGF-1 elevation
  • Supports lean muscle mass
  • Improves fat metabolism
  • Enhances sleep quality and recovery
Research NoteClinical studies show CJC-1295 DAC produces dose-dependent increases in GH levels with a favorable safety profile over extended use.
Starting at$200 / 5mg vial
GHRH Analogue

CJC-1295 NO DAC

A modified GHRH analogue without the DAC modification, producing a shorter, more pulsatile GH release that more closely mimics natural GH secretion patterns.

Key Benefits

  • Pulsatile GH release pattern
  • Supports natural GH rhythm
  • Lean muscle and fat loss support
  • Often stacked with Ipamorelin
Research NoteFrequently used in combination with Ipamorelin for synergistic GH optimization while maintaining physiological release patterns.
Starting at$200 / 10mg vial
IGF-1 Analogue

IGF-1 LR3

A long-acting analogue of Insulin-like Growth Factor 1 (IGF-1) with an arginine substitution that reduces binding to IGF-binding proteins, extending its activity and potency.

Key Benefits

  • Promotes muscle cell growth and repair
  • Enhances nutrient uptake in muscle
  • Supports fat metabolism
  • Longer half-life than native IGF-1
Research NoteIGF-1 LR3 has been studied for its anabolic and tissue-repair properties, with research showing enhanced muscle protein synthesis.
Starting at$155 / 1mg vial
GH Secretagogue

IPAMORELIN

A selective growth hormone secretagogue that stimulates GH release without significantly affecting cortisol, prolactin, or other hormones. Known for its clean GH pulse and excellent tolerability.

Key Benefits

  • Selective GH release
  • Minimal side effect profile
  • Supports lean body composition
  • Improves sleep and recovery
Research NoteIpamorelin is considered one of the most selective GH secretagogues available, with studies confirming its specificity and safety.
Starting at$200 / 10mg vial
GHRH Analogue

Sermorelin

The first 29 amino acids of endogenous GHRH, Sermorelin stimulates the pituitary to produce and release GH naturally. It is FDA-approved for GH deficiency in children and widely studied in adults.

Key Benefits

  • Stimulates natural GH production
  • Supports lean muscle and fat loss
  • Improves sleep quality
  • FDA-approved compound with long safety record
Research NoteDecades of clinical research support Sermorelin's safety and efficacy for GH optimization, with studies showing improvements in body composition and quality of life.
Starting at$200 / 10mg vial
GHRH Analogue

Tesamorelin

An FDA-approved GHRH analogue specifically studied for visceral fat reduction. Tesamorelin is particularly effective at targeting abdominal fat while preserving lean mass.

Key Benefits

  • Reduces visceral (abdominal) fat
  • FDA-approved for lipodystrophy
  • Improves IGF-1 levels
  • Preserves lean muscle mass
Research NoteMultiple Phase 3 clinical trials confirm Tesamorelin's efficacy in reducing visceral adipose tissue, with FDA approval for HIV-associated lipodystrophy.
Starting at$200 / 10mg vial
Longevity

Longevity Protocols

Cellular rejuvenation, mitochondrial health, DNA repair & anti-aging support

Tetrapeptide

Epitalon

A synthetic tetrapeptide (Ala-Glu-Asp-Gly) that stimulates telomerase activity, potentially lengthening telomeres — the protective caps on chromosomes associated with cellular aging.

Key Benefits

  • Stimulates telomerase activity
  • May extend cellular lifespan
  • Regulates melatonin production
  • Antioxidant and anti-aging properties
Research NoteDeveloped by the St. Petersburg Institute of Bioregulation, Epitalon has been studied for over 35 years with research showing telomere lengthening and lifespan extension in animal models.
Starting at$200 / 50mg vial
Copper Peptide

GHK-Cu

A naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. GHK-Cu has powerful regenerative, anti-inflammatory, and antioxidant properties affecting over 4,000 genes.

Key Benefits

  • Stimulates collagen and elastin synthesis
  • Promotes wound healing
  • Anti-inflammatory and antioxidant
  • Supports skin regeneration and hair growth
Research NoteResearch by Dr. Loren Pickart spanning decades shows GHK-Cu's broad regenerative effects, with studies confirming its role in activating tissue repair genes.
Starting at$50 / 50mg · $100 / 100mg
Coenzyme

NAD+

Nicotinamide adenine dinucleotide is a critical coenzyme found in every cell, essential for energy metabolism, DNA repair, and the activation of sirtuins — proteins linked to longevity.

Key Benefits

  • Supports cellular energy production
  • Activates longevity-linked sirtuins
  • Supports DNA repair mechanisms
  • May improve cognitive function and mood
Research NoteResearch from Harvard Medical School and the Sinclair Lab has established NAD+ as a central regulator of aging, with clinical trials showing improvements in energy, cognition, and metabolic health.
Starting at$80 / 500mg vial
Mitochondria-Targeted Peptide

SS-31

A cell-permeable tetrapeptide that specifically targets the inner mitochondrial membrane, reducing oxidative stress and improving mitochondrial function — a key driver of aging and metabolic decline.

Key Benefits

  • Reduces mitochondrial oxidative stress
  • Improves ATP production
  • Supports heart and kidney health
  • May slow age-related cellular decline
Research NoteSS-31 (Elamipretide) has been studied in multiple clinical trials for heart failure and kidney disease, with research confirming its mitochondrial protective effects.
Starting at$95 / 10mg · $295 / 50mg
Cognitive

Cognitive Protocols

Nootropic peptides for cognitive clarity, focus, neuroprotection & stress resilience

ACTH Analogue

SEMAX™

A synthetic analogue of ACTH (adrenocorticotropic hormone) developed in Russia, SEMAX enhances BDNF (brain-derived neurotrophic factor) production, supporting neuroplasticity, focus, and cognitive performance.

Key Benefits

  • Increases BDNF production
  • Enhances focus and mental clarity
  • Neuroprotective properties
  • Supports stress resilience
Research NoteApproved in Russia for stroke recovery and cognitive enhancement, SEMAX has been studied in clinical trials showing improvements in attention, memory, and neuroprotection.
Starting at$65 / 10mg vial
Anxiolytic Peptide

SELANK™

A synthetic analogue of the endogenous peptide tuftsin, SELANK has anxiolytic (anti-anxiety) and nootropic properties. It modulates GABA receptors and increases BDNF without sedation or dependence.

Key Benefits

  • Reduces anxiety without sedation
  • Improves memory and learning
  • Modulates GABA and serotonin systems
  • Non-habit forming anxiolytic
Research NoteApproved in Russia for anxiety and phobic disorders, SELANK clinical trials demonstrate significant anxiolytic effects comparable to benzodiazepines without the side effects or dependency risk.
Starting at$65 / 10mg vial
Specialty

Specialty Protocols

Addison Metabolic exclusive advanced formulas — beauty, regeneration, metabolic & recovery stacks

Addison Metabolic Exclusive

GLOW™

An exclusive Addison Metabolic beauty and skin regeneration formula combining synergistic peptides that target collagen synthesis, skin elasticity, and cellular renewal from within.

Key Benefits

  • Supports collagen and elastin production
  • Promotes skin radiance and elasticity
  • Cellular renewal and anti-aging
  • Exclusive Addison Metabolic formulation
Research NoteFormulated using peer-reviewed research on skin-active peptides. Consult your Addison Metabolic provider for full compound details.
Starting at$205 / 70mg vial
Addison Metabolic Exclusive

KLOW™

An exclusive Addison Metabolic formula designed to support joint health, reduce inflammation, and promote connective tissue longevity through a targeted peptide combination.

Key Benefits

  • Supports joint and cartilage health
  • Reduces chronic inflammation
  • Promotes connective tissue repair
  • Exclusive Addison Metabolic formulation
Research NoteFormulated using peer-reviewed research on joint-active peptides. Consult your Addison Metabolic provider for full compound details.
Starting at$225 / 80mg vial
Addison Metabolic Exclusive

RETA-PLUS™

An advanced metabolic stack exclusive to Addison Metabolic, combining GLP-3 pathway support with complementary metabolic peptides for comprehensive weight and energy management.

Key Benefits

  • Advanced metabolic pathway support
  • Complements GLP-1/GLP-3 therapies
  • Comprehensive weight and energy management
  • Exclusive Addison Metabolic formulation
Research NoteFormulated using peer-reviewed research on metabolic peptides. Consult your Addison Metabolic provider for full compound details.
Starting at$180 / 10mg vial
Addison Metabolic Exclusive

Wolverine Stack™

AMG's ultimate recovery and regeneration stack — a synergistic combination of the most powerful tissue repair and anti-inflammatory peptides for accelerated healing and resilience.

Key Benefits

  • Maximum tissue repair and regeneration
  • Comprehensive anti-inflammatory support
  • Accelerated recovery from injury or surgery
  • Exclusive Addison Metabolic formulation
Research NoteFormulated using peer-reviewed research on regenerative peptides. Consult your Addison Metabolic provider for full compound details.
Starting at$190 / 10mg vial

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